Propane dries our an engine. I would think the lack of lubricity with a diet of 100% pane would be harmful.
I had an idea that I never followed through on a few years ago concerning building a very simple system that could be used to inject a small amount of propane for added boost on steep hills. I was going to use a typical two-speed buton on the transmission shifter. Pull up on the button and get a boost, push it in and turn off the pane.
Furthermore, I've always felt that if a person wanted to go on a quest for optimum mileage that a small amount of propane introduced pre-turbo would make the dynamics of the fire deck more efficient. Just spit balling.