What general said. The wheel valves are leaking… bad or dirty diaphragms.
Everything after the PCU is controlled with air pressure and flow. The front axle dump valve is on the right side of the transmission. The dumps for the rear axles are on the crossmembers above those axles.
when CTIS cycles it seals the system(closes control solenoid) and gives a brief shot of supply air(supply solenoid) from the wet tank. This pressurizes the system above 5PSI. The dump valves send this pressure to the wheels which is enough to open the wheel valves. This connects all wheels with the PCU and the controller looks for a stable pressure on the pressure sensor located on the PCU. Here is where one particularly low tire can cause a fault, because as soon as the low tire is connected with the other fuller tires, the pressure try's to equalize . This can cause an unstable reading and the controller faults. Usually a few cycles will equalize the pressures enough that the controller gets an acceptable pressure and either adds air, releases air(deflate solenoid) or calls it good and releases the control solenoid.
releasing the control solenoid vents the PCU to zero pressure. The dumps see this on their input and mimic it on the wheel side output ports. As the wheel pressure falls below 5PSI the wheel valves should slam shut, so the dump valves all vent briefly. If it continues to vent 1 of 2 things is likely happening, wheel valves as General mentioned are not re-sealing, or there is a restriction somewhere that is preventing the pressure from dropping cleanly below 5PSI and the tire pressure continues to feed the dump valve which continues to vent the air until the decreasing tire pressure cannot feed enough air to keep the truck side of the wheel valve over 5PSI and it closes.
This has been a fairly common issue I have helped troubleshoot with the main PCU vent being clogged by insects. When the controller ends a cycle it opens control but the system does not cleanly vent below 5PSI because of the clog and proceeds to deflate all the tires until the flow out of the tires finally gets low enough to allow the truck side pressure low enough for the wheel valves to close.
if it is a single wheel on an axle, probably a wheel valve. If it is 2 wheels on an axle it could be a dump valve sticking or a clog associated with that dump. Or both wheel valves on the two wheels… all wheels, probably a clog on the main vent line out of the PCU or a sticky PCU control valve.
put a jack stand under the axle at the wheel you are working on and let the air out of the tire. Remove the 4 screws on the wheel valve to access the diaphragm and a spring. Behind the diaphragm, you will find a small hole in the center that is where the rubber diaphragm seals the port into the tire(center hole). clean the center seat around that hole and you most likely need a new diaphragm. I had one wheel that leaked and the diaphragm was fine, just some crap fouling the center hole…
good luck!